I’m a chef, im on my feet all day I have two kitchen jobs 7am to 11pm. My lower back is starting to get really tired and a little bit I’d pain should I use Kratom for the pain ?
sorry man but kratom is no where close to withdrawing from oxycontin. and pharmaceuticals are not selective they target all opiates in the body. the only pharmaceutical opiate that is selective is suboxone its a partial antagonist. and even suboxone has worse withdrawals then kratom . kratom isn't that bad compared to hydrocodone and oxycodone man trust me .
I take kratom … it makes me eat like nobody's business.. also when I use the bathroom I feel like I'm giving birth no watery stool. So far the best brand I have tried and I've tried many .. is happy hippo kratom
This is the first video of yours I watched and you get an immediate sub. Was on hydrocodone for 4 years for post-surgical pain then was forced to quit quickly 2 years ago when my doctor died suddenly. I was left taking gabapentin only, which wasn't giving me a great quality of life, so when I saw a Joey video on Kratom (then a bunch more) I decided to try it. It was so great at first that I used it to get off of gabapentin completely. Now I almost wish I'd never heard of it. To be clear, I've chosen to suffer rather than let my daily use ever get huge, but still taking breaks is really difficult, and the level of benefits achieved at first does not appear to be sustainable long term, at least not without a level of expense I can't afford. This video of yours gives the proper level of caution, which I appreciate much. Looking forward to seeing more
You hit the nail on the head man. I have been using for 2 years and it got outta hand quickly. Lately I've been getting pains in my abdomen so I'm stopping. You're right about it fucking up hormones. I was bulking up too and lost so much weight. It's fucking bad
Great video and much appreciated! The overall info re Kratom use is good. However, I’ve been using Kratom daily for two months with a few episodes of withdrawal, but, having taken OxyContin regularly in the past for hip pain, the withdrawal from Kratom, compared with OxyContin, is a “walk in the park”; it’s real, but no way near as bad and can be managed with little effort. Best regards!
Good stuff but I’ll like to add respectfully that most troubled with Kratom don’t discuss abuse itself- abuse is taking more and more and more, so all the science stuff about receptor’s etc sounds smart but It’s simple, don’t eat cake every day or face weight gain along with all the problems related to weight gain. It’s the same with alcohol, drugs etc, you’re not supposed to take massive amounts of anything and if you do, then…..isn’t it greed? or do we substitute greed with words like addiction cause it sounds sweeter?
I listen to Joey and came across your channel today. As an recovering alcoholic and addict, I can attest to the risks. The key point I get from this and Joey's channel is to treat Kratom with respect. I went through a phase where I was taking too much and experienced mild withdrawal symptoms but they did not affect me that badly. I use a journal to track my intake and take a break every 6 weeks. Tapering dosages' has helped greatly with withdrawals. I'm glad to share any experiences with that if anyone needs help or encouragement.
Your so full of sh*t I don't know where to start,first off yes Kratom is an opioid it has been proven it is fact, look up Hamilton Morris and learn some stuff first hand before you spew your bs.2nd it is far less addictive than any other opioid on earth and you can come off it very easy if you know how to taper your doses everyday.I took 20 grams a day for around a year with no problems except tolerance,so I instantly cut to 16 grams a day for maybe a month, zero problems,after that month I cut it to 8 grams a day and had a tiny bit of sleep problems and sweat a tiny bit a common cold would be much worse.I have been taking Kratom for a little over 5 years and unlike you I was a hardcore addict on opiates and alcohol I had overdosed many times and hospitalized a couple on my deathbed and they brought me back.I have been sober for a little over 5 years because of kratom.I was on dilaudid among many other opiates and for you to compare the two is just strait laughable anyone reading this if you have an opiate problem or even alcohol give a good safe kratom a chance,this muscle dummy has no idea what the f*ck he is talking about.If you are dope sick just try 5 grams of a good red and tell me it is bad…
Finally a video that I'm able to find acknowledgement from what I've been experiencing as far as the pain. My L5 -S1 is damaged and I also have 6 children doing it alone im looking for a pain relief alternative. This chronic pain is agonizing and just to Finally have someone explain what I feel just makes me feel understood. Can you give me some advice on how to move forward with pain manage waking up is so difficult because of the stiffness and the aching all through the day. I don't talk about my suffering much because I was raised to hold in pain. I'm on tramdol now I feel so much guilt when I do and I try to limit as much as I can the issues is if I don't I can barely function for my children especially being the only support they have im emotionally and physically overwhelmed. Thankfully my spirit is strong. Thank you for your in depth insight 🙏
I hear you and respect what your saying, but you're speaking from personal experience. There are also a ton of people with the complete opposite experience as you. Kratom IS NOT a one size fits all supplement. That is what I have found out in my 6 yrs of taking kratom and advocating for kratom.
I watched your videos on your recovery from surgery as I am having surgery next week. I’m not sure if you have tried using a TENS machine or not but I’m in so much pain pre-surgery I thought I would mention it as I got one yesterday and it’s a great means of alternative non-medicated pain management. I use it along with my prescription painkillers when I’m just lying on my bed. I saw that if you’re in the US you may need a doctors prescription for it (I’m in New Zealand and we can just buy them over the counter at pharmacies etc), but if you could even just hire one to see if it works for you, I recommend giving it a shot.
This vid is helpful! I’m a daily user 2x per day but as u said I have noticed that maybe I should start taking an extra dose for my fibromyalgia break through pain which scares me.
2021 NIDA DIRECTOR’S REPORT on Kratom Nora D. Volkow, M.D. Dir National Institute Drug Abuse
“initial findings indicate mitragynine and 7-hydroxymitragynine are not rewarding in ICSS procedure. present results suggest kratom alkaloids do not have abuse potential.”
NIH RECORD on Kratom June 24, 2022 Vol. LXXIV, No. 13 Dr McCurdy “traditional kratom withdrawal tends to be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
IN THIS ISSUE ‘COMPLEX SYMPHONY ORCHESTRA’ McCurdy Studies Whether Kratom Can Reduce Opioid Withdrawal, Ease Pain
(Kratom)”MG occurs naturally in the plant. It’s considered a partial opioid receptor agonist, though McCurdy said he wouldn’t lump it in the traditional opioid category”
NIH published Yale University. Focus: “Plant-based Medicine and Pharmacology: Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study”
Methods:
Kratom effects on pain tolerance were assessed in a randomized, placebo-controlled, double-blind study. During a 1-day inpatient stay, participants received a randomized sequence of kratom and placebo decoctions matched for taste and appearance. Pain tolerance was measured objectively in a cold pressor task (CPT) as time (seconds) between the pain onset and the hand withdrawal from the ice bath. Health status, vital signs, objective, and subjective indicators of withdrawal symptoms, self-reported data on lifetime kratom use patterns, and assessments of blinding procedures were also evaluated.
Conclusions:
Kratom decoction demonstrated a substantial and statistically significant increase in pain tolerance. Further rigorous research on kratom pain-relieving properties and a safety profile is needed.
Kratom and pain relief NIH published National Library of Medicine
Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method Erin C Berthold et al. J Pharm Biomed Anal. 2021.
“Speciociliatine is a minor indole alkaloid found in kratom, a southeast Asian medicinal plant, used for centuries to increase energy, enhance mood, and mitigate pain and opioid dependence.”
The leader of the NIH and NIDA Kratom research team believes Kratom is part of the solution to the opioid cris for both pain patient and/or addict
April 25 2022 Dr. Christopher McCurdy of the University of Florida discussed the traditional medicinal use of kratom, current pharmacologic studies on this drug, and the results of his team’s behavioral studies on this drug.
April 25 Lecture To Explore Kratom’s Therapeutic Potential in Opioid Addiction
Oxidative Metabolism as a Modulator of Kratom’s Biological Actions
Soumen Chakraborty, Ph.D., postdoctoral research associate in the Center for Clinical Pharmacology
“Chakraborty’s new research indicates that the metabolism of mitragynine in mice leads to the formation of a potent mu opioid receptor agonist capable of treating severe acute pain without the negative side effects associated with traditional opioid pain relievers.”
Withdrawals? NIH & NIDA pain and addiction Kratom research scientist has determined…..
NIH RECORD on Kratom June 24, 2022 Vol. LXXIV, No. 13 Dr McCurdy “traditional kratom withdrawal tends to be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
Is coffee addictive? Are you addicted to chocolate?
Asking questions like this is a bit misguided. In none of these examples we ask whether plants themselves are addictive. Instead, we question the potential for abuse of active alkaloids in each plant.
Alkaloids: one of a class of nitrogenous organic compounds derived from plants that have been pronounced physiological actions in humans.
In simple English, alkaloids are any chemicals in plants that cause real effects when consumed by humans. Caffeine, for example, is an active alkaloid in coffee beans that is responsible for the stimulating effect of coffee. Nicotine is an alkaloid in tobacco, and theobromine & caffeine are alkaloids in chocolate (chocolate).
There are about 20 active alkaloids in the Kratom plant. The two dominant alkaloids responsible for plant effects are Mitragynine (MG) and 7-hydroxymitragynine (7-HMG). Of all the alkaloids in Kratom, MG is the most common, making up about 60% of all alkaloid profiles. In contrast, 7-HMG only makes up 2% of the alkaloid profile. Therefore, it is believed that MG is the alkaloid responsible for most of the effects reported by Kratom users; such as relieving anxiety, relieving pain and regulating moods.
"The main effect of kratom is most likely produced by MG with the possible contribution of 7-OH-MG.
(from Pinney Associates's 8-factor analysis of potential kratom abuse)
With this in mind, we should reframe a little the original question: Is Mitragynine addictive?
According to a study conducted by the Society for the Study of Addiction published in June '18 in the Journal of Addiction Biology (a peer-reviewed academic journal), "These findings indicate that MG has no potential for abuse and reduces morphine intake, a desirable characteristic of pharmacotherapy candidates for opiate addiction and withdrawal … "So, in other words, MG does not match the potential abuse profile assigned to addictive substances, such as heroin and Oxycontin. More about that here. In fact, in the study, they gave mice with Morphine for several days in a row, and then turned it into MG for several days. After their time with MG, Morphine was again available to them, and they showed a reduced likelihood of returning to using Morphine. This is what is referred to in the quote above when they show that it "reduces morphine intake". Which, as the authors say, makes it a very promising potential therapy for opiate & withdrawal addiction.
In addition, when looking at potential drug abuse, the main factor considered is the effect that the substance has on the daily lives of users. For example, the majority of cocaine or heroin users report a drastic negative impact on their ability to engage with work, friends, and life in general. The use of kratom does not fit this description at all. In fact, according to Pinney Associates 8-factor analysis, "Consumption usually does not interfere with work or social activities and commitments, and in fact kratom is widely reported in the US, as in Southeast Asia, to contribute to work productivity, quality of life, and social relations. "So, unlike abuse drugs, kratom seems to improve the quality of life for many users, as opposed to reducing it. It is interesting to read this description as presented by scientific research.”
World Health Organization WHO was asked to do a critical 1 year review in Oct of 2021. In a 4 day hearing they couldn’t find any reason for a review
Expect Committee in Drug Dependsnce from the WHO World Health Organization has determined there’s insufficient information to even review KRATOM further. The concluded to leave it at the same level of surveillance as it had been for years.
Kratom tea primarily exerts its actions through the mu opioid receptor.
Kratom tea produced no sedative effects and minimum respiratory depression.
Kratom tea ameliorated opioid withdrawal symptoms both chronically and acutely.
Conclusions The present study confirms the MOR agonist activity and therapeutic effect of LKT for the treatment of pain and opioid physical dependence.”
Kratom compared to MAT NIH National Library of Medicine National Center for Biotechnology Information
Mitragynine Attenuates Morphine Withdrawal Effects in Rats-A Comparison With Methadone and Buprenorphine Rahimah Hassan et al. Front Psychiatry. 2020.
“suggests mitragynine as alternative treatment opiate withdrawal effects as buprenorphine. While mitragynine is equally effective in reducing opiate withdrawal effects in rats, it may be the safer drug with less undesired side-effects.”
“Speciociliatine is a minor indole alkaloid found in kratom, a southeast Asian medicinal plant, used for centuries to increase energy, enhance mood, and mitigate pain and opioid dependence.”
Advanced Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method
“Mitragynine and 7-hydroxymitragynine are the primary active alkaloids responsible for the effects of kratom. Despite its interaction with opioid receptors, mitragynine is not structurally similar to traditional opioid medications.”
“Another key difference between kratom and traditional opioids is the lack of beta-arrestin-2 recruitment, which may explain the reduced side effects and risk of respiratory depression seen with kratom”
“It has been postulated that in addition to the opioid receptor effects, kratom may provide a second mechanism to potentially alleviate pain with these pathways that have already been well characterized and utilized for modern approaches to pain management with TCAs and SNRI medications.7 There is also evidence to suggest kratom has anti-inflammatory effects from cyclooxygenase-2 inhibition.”
Volume 20, Issue 5 A Kratom Primer: Miracle Medicine or Herb of Abuse?
Effects of Kratom on kidneys, liver, thyroid and glucose
(I even have a damaged kidney from a birth defect. I was told the kidney would need to be removed when I got to be 40-50. I’m 57 and no issues whatsoever with my kidneys)
“There were no significant alterations found in the hematological and biochemical of kratom users, except for a decrease in white cell count after a 3-month interval. In general, the kidney, liver function tests, thyroid, and glucose parameters were not significantly affected. Calcium, total protein, and globulin levels were significantly increased at T2 compared to T1, but all these parameters were within the normal reference range. There were alterations in the lipid profile, where total cholesterol and LDL cholesterol parameters were elevated at both T1 and T2, while significant increase in HDL cholesterol, and decrease in triglycerides levels were observed at T2 compared to T1.
Conclusion
Our results indicated that continuous consumption of kratom decoction at a daily mitragynine dose of 76.3–114.8 mg did not appear to alter the safety hematological and biochemical parameters of kratom users.”
Journal of Substance Use Research Article Comparison of biochemical and safety parameters of regular kratom (Mitragyna speciosa Korth.) users at two different time periods
“Anti-inflammatory effects and potential mechanisms of Mitragyna speciosa methanol extract on λ-karagenan-induced inflammation model.
CONCLUSION This study suggested that Methanol extract of Mitragyna (EMS) Speciosa possesses anti-inflammatory effects in carrageenan-induced rat paw edema. The anti-inflammatory mechanism of EMS may be related to protecting the skin thickness. Our study findings provide new perspectives on the therapeutic use of EMS in the management of inflammatory diseases.”
Withdrawals? NIH & NIDA pain and addiction Kratom research scientist has determined…..
NIH RECORD on Kratom June 24, 2022 Vol. LXXIV, No. 13 Dr McCurdy “traditional kratom withdrawal tends to be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
👌
I’m a chef, im on my feet all day I have two kitchen jobs 7am to 11pm. My lower back is starting to get really tired and a little bit I’d pain should I use Kratom for the pain ?
sorry man but kratom is no where close to withdrawing from oxycontin. and pharmaceuticals are not selective they target all opiates in the body. the only pharmaceutical opiate that is selective is suboxone its a partial antagonist. and even suboxone has worse withdrawals then kratom . kratom isn't that bad compared to hydrocodone and oxycodone man trust me .
I take kratom … it makes me eat like nobody's business.. also when I use the bathroom I feel like I'm giving birth no watery stool. So far the best brand I have tried and I've tried many .. is happy hippo kratom
This is the first video of yours I watched and you get an immediate sub. Was on hydrocodone for 4 years for post-surgical pain then was forced to quit quickly 2 years ago when my doctor died suddenly. I was left taking gabapentin only, which wasn't giving me a great quality of life, so when I saw a Joey video on Kratom (then a bunch more) I decided to try it. It was so great at first that I used it to get off of gabapentin completely. Now I almost wish I'd never heard of it. To be clear, I've chosen to suffer rather than let my daily use ever get huge, but still taking breaks is really difficult, and the level of benefits achieved at first does not appear to be sustainable long term, at least not without a level of expense I can't afford. This video of yours gives the proper level of caution, which I appreciate much. Looking forward to seeing more
Id love to hear more about kratom and the TRT. I set up a doctor appointment to get my hormones, thyroid checked and im curious.
Sir how can I get in touch with you??? Keep going with these plzzz
Hey Adam. Happy thanksgiving!!
You hit the nail on the head man. I have been using for 2 years and it got outta hand quickly. Lately I've been getting pains in my abdomen so I'm stopping. You're right about it fucking up hormones. I was bulking up too and lost so much weight. It's fucking bad
Great video and much appreciated! The overall info re Kratom use is good. However, I’ve been using Kratom daily for two months with a few episodes of withdrawal, but, having taken OxyContin regularly in the past for hip pain, the withdrawal from Kratom, compared with OxyContin, is a “walk in the park”; it’s real, but no way near as bad and can be managed with little effort. Best regards!
If that's not high, how do you define high?
Good stuff but I’ll like to add respectfully that most troubled with Kratom don’t discuss abuse itself- abuse is taking more and more and more, so all the science stuff about receptor’s etc sounds smart but It’s simple, don’t eat cake every day or face weight gain along with all the problems related to weight gain. It’s the same with alcohol, drugs etc, you’re not supposed to take massive amounts of anything and if you do, then…..isn’t it greed? or do we substitute greed with words like addiction cause it sounds sweeter?
I'm a big advocate of moderate kratom use, but if it binds to the opioid receptors, its an opioid..
I listen to Joey and came across your channel today. As an recovering alcoholic and addict, I can attest to the risks. The key point I get from this and Joey's channel is to treat Kratom with respect. I went through a phase where I was taking too much and experienced mild withdrawal symptoms but they did not affect me that badly. I use a journal to track my intake and take a break every 6 weeks. Tapering dosages' has helped greatly with withdrawals. I'm glad to share any experiences with that if anyone needs help or encouragement.
Your so full of sh*t I don't know where to start,first off yes Kratom is an opioid it has been proven it is fact, look up Hamilton Morris and learn some stuff first hand before you spew your bs.2nd it is far less addictive than any other opioid on earth and you can come off it very easy if you know how to taper your doses everyday.I took 20 grams a day for around a year with no problems except tolerance,so I instantly cut to 16 grams a day for maybe a month, zero problems,after that month I cut it to 8 grams a day and had a tiny bit of sleep problems and sweat a tiny bit a common cold would be much worse.I have been taking Kratom for a little over 5 years and unlike you I was a hardcore addict on opiates and alcohol I had overdosed many times and hospitalized a couple on my deathbed and they brought me back.I have been sober for a little over 5 years because of kratom.I was on dilaudid among many other opiates and for you to compare the two is just strait laughable anyone reading this if you have an opiate problem or even alcohol give a good safe kratom a chance,this muscle dummy has no idea what the f*ck he is talking about.If you are dope sick just try 5 grams of a good red and tell me it is bad…
What do you think about using Kratom to get off Suboxone?
Part 2 – https://youtu.be/r_-HLfoRRfY
Finally a video that I'm able to find acknowledgement from what I've been experiencing as far as the pain. My L5 -S1 is damaged and I also have 6 children doing it alone im looking for a pain relief alternative. This chronic pain is agonizing and just to Finally have someone explain what I feel just makes me feel understood. Can you give me some advice on how to move forward with pain manage waking up is so difficult because of the stiffness and the aching all through the day. I don't talk about my suffering much because I was raised to hold in pain. I'm on tramdol now I feel so much guilt when I do and I try to limit as much as I can the issues is if I don't I can barely function for my children especially being the only support they have im emotionally and physically overwhelmed. Thankfully my spirit is strong. Thank you for your in depth insight 🙏
I hear you and respect what your saying, but you're speaking from personal experience. There are also a ton of people with the complete opposite experience as you. Kratom IS NOT a one size fits all supplement. That is what I have found out in my 6 yrs of taking kratom and advocating for kratom.
I watched your videos on your recovery from surgery as I am having surgery next week. I’m not sure if you have tried using a TENS machine or not but I’m in so much pain pre-surgery I thought I would mention it as I got one yesterday and it’s a great means of alternative non-medicated pain management. I use it along with my prescription painkillers when I’m just lying on my bed. I saw that if you’re in the US you may need a doctors prescription for it (I’m in New Zealand and we can just buy them over the counter at pharmacies etc), but if you could even just hire one to see if it works for you, I recommend giving it a shot.
As always another very helpful video brother.
Hope all is well my friend ❤️
This vid is helpful! I’m a daily user 2x per day but as u said I have noticed that maybe I should start taking an extra dose for my fibromyalgia break through pain which scares me.
2021 NIDA DIRECTOR’S REPORT on Kratom
Nora D. Volkow, M.D. Dir National Institute Drug Abuse
“initial findings indicate mitragynine and 7-hydroxymitragynine are not rewarding in ICSS procedure. present results suggest kratom alkaloids do not have abuse potential.”
NIH RECORD on Kratom
June 24, 2022
Vol. LXXIV, No. 13
Dr McCurdy
“traditional kratom withdrawal tends to
be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
Is Kratom an opioid?
NIH Record – National Institutes of Health
June 24, 2022
IN THIS ISSUE
‘COMPLEX SYMPHONY ORCHESTRA’
McCurdy Studies Whether Kratom Can Reduce Opioid Withdrawal, Ease Pain
(Kratom)”MG occurs naturally in the plant. It’s considered a partial opioid receptor agonist, though McCurdy said he wouldn’t lump it in the traditional opioid category”
NIH published Yale University. Focus: “Plant-based Medicine and Pharmacology: Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study”
Methods:
Kratom effects on pain tolerance were assessed in a randomized, placebo-controlled, double-blind study. During a 1-day inpatient stay, participants received a randomized sequence of kratom and placebo decoctions matched for taste and appearance. Pain tolerance was measured objectively in a cold pressor task (CPT) as time (seconds) between the pain onset and the hand withdrawal from the ice bath. Health status, vital signs, objective, and subjective indicators of withdrawal symptoms, self-reported data on lifetime kratom use patterns, and assessments of blinding procedures were also evaluated.
Conclusions:
Kratom decoction demonstrated a substantial and statistically significant increase in pain tolerance. Further rigorous research on kratom pain-relieving properties and a safety profile is needed.
Kratom and pain relief
NIH published
National Library of Medicine
Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method
Erin C Berthold et al. J Pharm Biomed Anal. 2021.
“Speciociliatine is a minor indole alkaloid found in kratom, a southeast Asian medicinal plant, used for centuries to increase energy, enhance mood, and mitigate pain and opioid dependence.”
The leader of the NIH and NIDA Kratom research team believes Kratom is part of the solution to the opioid cris for both pain patient and/or addict
April 25 2022 Dr. Christopher McCurdy of the University of Florida discussed the traditional medicinal use of kratom, current pharmacologic studies on this drug, and the results of his team’s behavioral studies on this drug.
April 25 Lecture To Explore Kratom’s Therapeutic Potential in Opioid Addiction
New Reaearch on Kratom for pain relief.
Oxidative Metabolism as a Modulator of Kratom’s Biological Actions
Soumen Chakraborty, Ph.D., postdoctoral research associate in the Center for Clinical Pharmacology
“Chakraborty’s new research indicates that the metabolism of mitragynine in mice leads to the formation of a potent mu opioid receptor agonist capable of treating severe acute pain without the negative side effects associated with traditional opioid pain relievers.”
Withdrawals? NIH & NIDA pain and addiction Kratom research scientist has determined…..
NIH RECORD on Kratom
June 24, 2022
Vol. LXXIV, No. 13
Dr McCurdy
“traditional kratom withdrawal tends to
be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
“Is Kratom addictive?
Is coffee addictive? Are you addicted to chocolate?
Asking questions like this is a bit misguided. In none of these examples we ask whether plants themselves are addictive. Instead, we question the potential for abuse of active alkaloids in each plant.
Alkaloids: one of a class of nitrogenous organic compounds derived from plants that have been pronounced physiological actions in humans.
In simple English, alkaloids are any chemicals in plants that cause real effects when consumed by humans. Caffeine, for example, is an active alkaloid in coffee beans that is responsible for the stimulating effect of coffee. Nicotine is an alkaloid in tobacco, and theobromine & caffeine are alkaloids in chocolate (chocolate).
There are about 20 active alkaloids in the Kratom plant. The two dominant alkaloids responsible for plant effects are Mitragynine (MG) and 7-hydroxymitragynine (7-HMG). Of all the alkaloids in Kratom, MG is the most common, making up about 60% of all alkaloid profiles. In contrast, 7-HMG only makes up 2% of the alkaloid profile. Therefore, it is believed that MG is the alkaloid responsible for most of the effects reported by Kratom users; such as relieving anxiety, relieving pain and regulating moods.
"The main effect of kratom is most likely produced by MG with the possible contribution of 7-OH-MG.
(from Pinney Associates's 8-factor analysis of potential kratom abuse)
With this in mind, we should reframe a little the original question: Is Mitragynine addictive?
According to a study conducted by the Society for the Study of Addiction published in June '18 in the Journal of Addiction Biology (a peer-reviewed academic journal), "These findings indicate that MG has no potential for abuse and reduces morphine intake, a desirable characteristic of pharmacotherapy candidates for opiate addiction and withdrawal … "So, in other words, MG does not match the potential abuse profile assigned to addictive substances, such as heroin and Oxycontin. More about that here. In fact, in the study, they gave mice with Morphine for several days in a row, and then turned it into MG for several days. After their time with MG, Morphine was again available to them, and they showed a reduced likelihood of returning to using Morphine. This is what is referred to in the quote above when they show that it "reduces morphine intake". Which, as the authors say, makes it a very promising potential therapy for opiate & withdrawal addiction.
In addition, when looking at potential drug abuse, the main factor considered is the effect that the substance has on the daily lives of users. For example, the majority of cocaine or heroin users report a drastic negative impact on their ability to engage with work, friends, and life in general. The use of kratom does not fit this description at all. In fact, according to Pinney Associates 8-factor analysis, "Consumption usually does not interfere with work or social activities and commitments, and in fact kratom is widely reported in the US, as in Southeast Asia, to contribute to work productivity, quality of life, and social relations. "So, unlike abuse drugs, kratom seems to improve the quality of life for many users, as opposed to reducing it. It is interesting to read this description as presented by scientific research.”
World Health Organization
WHO was asked to do a critical 1 year review in Oct of 2021. In a 4 day hearing they couldn’t find any reason for a review
Expect Committee in Drug Dependsnce from the WHO World Health Organization has determined there’s insufficient information to even review KRATOM further. The concluded to leave it at the same level of surveillance as it had been for years.
It’s important to note the DRAMATIC difference between adulterated vs non adulterated.
Issues are when the 7-OH alkaloid is artificially inflated by 500%. In the plain leaf it’s only 2%
Mother nature got it right but you know we humans always feel that we are so superior that we have to try and improve on everything
NIH and NIDA funded research
“Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence
Received 15 June 2020, Revised 13 September 2020, Accepted 15 September 2020, Available online 22 September 2020.
Highlights
Kratom tea dose dependently produces antinociceptive effects.
Kratom tea primarily exerts its actions through the mu opioid receptor.
Kratom tea produced no sedative effects and minimum respiratory depression.
Kratom tea ameliorated opioid withdrawal symptoms both chronically and acutely.
Conclusions
The present study confirms the MOR agonist activity and therapeutic effect of LKT for the treatment of pain and opioid physical dependence.”
Kratom compared to MAT
NIH National Library of Medicine
National Center for Biotechnology Information
Mitragynine Attenuates Morphine Withdrawal Effects in Rats-A Comparison With Methadone and Buprenorphine
Rahimah Hassan et al. Front Psychiatry. 2020.
“suggests mitragynine as alternative treatment opiate withdrawal effects as buprenorphine. While mitragynine is equally effective in reducing opiate withdrawal effects in rats, it may be the safer drug with less undesired side-effects.”
Kratom and pain relief
NIH National Library of Medicine
“Speciociliatine is a minor indole alkaloid found in kratom, a southeast Asian medicinal plant, used for centuries to increase energy, enhance mood, and mitigate pain and opioid dependence.”
Advanced
Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method
“Mitragynine and 7-hydroxymitragynine are the primary active alkaloids responsible for the effects of kratom. Despite its interaction with opioid receptors, mitragynine is not structurally similar to traditional opioid medications.”
“Another key difference between kratom and traditional opioids is the lack of beta-arrestin-2 recruitment, which may explain the reduced side effects and risk of respiratory depression seen with kratom”
“It has been postulated that in addition to the opioid receptor effects, kratom may provide a second mechanism to potentially alleviate pain with these pathways that have already been well characterized and utilized for modern approaches to pain management with TCAs and SNRI medications.7 There is also evidence to suggest kratom has anti-inflammatory effects from cyclooxygenase-2 inhibition.”
Volume 20, Issue 5
A Kratom Primer: Miracle Medicine or Herb of Abuse?
Effects of Kratom on kidneys, liver, thyroid and glucose
(I even have a damaged kidney from a birth defect. I was told the kidney would need to be removed when I got to be 40-50. I’m 57 and no issues whatsoever with my kidneys)
“There were no significant alterations found in the hematological and biochemical of kratom users, except for a decrease in white cell count after a 3-month interval. In general, the kidney, liver function tests, thyroid, and glucose parameters were not significantly affected. Calcium, total protein, and globulin levels were significantly increased at T2 compared to T1, but all these parameters were within the normal reference range. There were alterations in the lipid profile, where total cholesterol and LDL cholesterol parameters were elevated at both T1 and T2, while significant increase in HDL cholesterol, and decrease in triglycerides levels were observed at T2 compared to T1.
Conclusion
Our results indicated that continuous consumption of kratom decoction at a daily mitragynine dose of 76.3–114.8 mg did not appear to alter the safety hematological and biochemical parameters of kratom users.”
Journal of Substance Use
Research Article
Comparison of biochemical and safety parameters of regular kratom (Mitragyna speciosa Korth.) users at two different time periods
Kratom anti inflammatory effects.
“Anti-inflammatory effects and potential mechanisms of Mitragyna speciosa methanol extract on λ-karagenan-induced inflammation model.
CONCLUSION
This study suggested that Methanol extract of Mitragyna (EMS) Speciosa possesses anti-inflammatory effects in carrageenan-induced rat paw edema. The anti-inflammatory mechanism of EMS may be related to protecting the skin thickness. Our study findings provide new perspectives on the therapeutic use of EMS in the management of inflammatory diseases.”
Withdrawals? NIH & NIDA pain and addiction Kratom research scientist has determined…..
NIH RECORD on Kratom
June 24, 2022
Vol. LXXIV, No. 13
Dr McCurdy
“traditional kratom withdrawal tends to
be mild. “It’s in the upper end of mild,” McCurdy said, “but it’s not in moderate and it’s certainly not in severe.”
Wow all I can say you hit everything on the head………omg wow 😱
Is there a company or brand you can recommend for pain?